COMPLEX OF 1-(2-HYDROXYETHYL)-2-METHYL-5-NITROIMIDAZOLE WITH POLYVINYLPYRROLIDONE, METHOD OF ITS PREPARING AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL EFFECT Russian patent published in 2000 - IPC

Abstract RU 2157384 C2

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to chemistry of biologically active polymers and preparing the sustained-release antibacterial preparations. Invention describes the novel complex of 1-(2-hydroxyethyl)-2- -methyl-5-nitroimidazole with polyvinylpyrrolidone of the formula (I) where n = 81-539 (molecular mass is 9000- -60000 Da). Obtained complex shows the broad spectrum of antibacterial effect and can be used in suppurative surgery, gynecology, maxillofacial surgery and other branches of medicine as a drug. Invention describes also method of its preparing and pharmaceutical composition showing antibacterial effect. EFFECT: new complex indicated above, valuable antibacterial effect. 6 cl, 1 tbl, 3 ex

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RU 2 157 384 C2

Authors

Lopyrev V.A.

Rozinova L.G.

Protsuk N.I.

Grigor'Ev E.G.

Kogan A.S.

Kuznetsova Eh.Eh.

Astakhova A.V.

Mikhalev B.V.

Tarasov N.V.

Kamyshanov A.V.

Dates

2000-10-10Published

1998-08-27Filed