FIELD: organic chemistry. SUBSTANCE: products: derivatives of piperidine of the formula (I) given in description where A and B taken together mean -CH2CH2-, or A and B taken separately and each means H; X - CH2 or O; X1 - H or OH; Z - H, F, Cl or OH; Z1 - H, F, Cl, Br or C1-C3-alkyl; n = 0 or 1; m = 0, 1 or 2. Reagent 1: compound of the formula (II) given in description where all substituents have values as indicated for compound (I). Reagent 2: reducing agent, for example NaBH4 or LiAlH4. Reaction conditions: in medium of inert solvent, at (-15)-(+15) C. The synthesized compounds were used in medicine as neuroprotecting agents. EFFECT: improved method of synthesis. 17 cl, 1 tbl
Authors
Dates
1997-12-20—Published
1992-08-05—Filed