HYDROGENATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, DERIVATIVES OF PYPERIDINE, PHARMACEUTICAL COMPOSITION AND METHOD FOR SUPPRESSING ACTIVITY OF P COMPOUND IN ORGANISM Russian patent published in 1998 - IPC

Abstract RU 2105758 C1

FIELD: medicine, namely, treatment and prevention of inflammatory conditions and injury of central nervous system. SUBSTANCE: hydrogenated nitrogen-containing compounds have formula I where y-(CH2)n is group, wherein n is 2,3 or 4, m is 0-6, R1 is hydrogen, C1-C6-alkyl, R2 is hydrogen, methyl, tert-butyl, C5-C6-cycloalkyl, benzyl, benzohydryl, naphthyl, thienyl, furanyl, indanyl, phenyl, R3 is unsubstituted or substituted phenyl, R4 is hydrogen, methyl, methoxy, halogen, R5 is hydrogen, R6 is hydrogen, phenyl, hydroxyl, phenoxy, amino, cyano, carboxy, carbethoxy, acetamido, benzamido, 4, 41-difluorobenzhydryl, carboxamido, R7 is hydrogen, R8 is hydrogen or hydroxyl. Intermediate compounds have formula II where R1-R5 and R7 are mentioned above. Pharmaceutical composition comprises compound having formula I as active substance. EFFECT: improved quality and efficiency of the method. 10 cl, 7 tbl

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RU 2 105 758 C1

Authors

Manodzh S.Desaj[In]

Terri Dzh.Rosen[Us]

Dates

1998-02-27Published

1991-12-23Filed