FIELD: medicine, namely, treatment and prevention of inflammatory conditions and injury of central nervous system. SUBSTANCE: hydrogenated nitrogen-containing compounds have formula I where y-(CH2)n is group, wherein n is 2,3 or 4, m is 0-6, R1 is hydrogen, C1-C6-alkyl, R2 is hydrogen, methyl, tert-butyl, C5-C6-cycloalkyl, benzyl, benzohydryl, naphthyl, thienyl, furanyl, indanyl, phenyl, R3 is unsubstituted or substituted phenyl, R4 is hydrogen, methyl, methoxy, halogen, R5 is hydrogen, R6 is hydrogen, phenyl, hydroxyl, phenoxy, amino, cyano, carboxy, carbethoxy, acetamido, benzamido, 4, 41-difluorobenzhydryl, carboxamido, R7 is hydrogen, R8 is hydrogen or hydroxyl. Intermediate compounds have formula II where R1-R5 and R7 are mentioned above. Pharmaceutical composition comprises compound having formula I as active substance. EFFECT: improved quality and efficiency of the method. 10 cl, 7 tbl
Authors
Dates
1998-02-27—Published
1991-12-23—Filed