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2 102 395

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IPC

(21) (22)

Application

96101599/04, 1996-01-24

(22)

Actual filing date

1996-01-24

(45)

Published

1998-01-20

(72)

Inventor

Beklemishev A.B.Pichko N.P.Karjagin A.Ju.

(73)

Holder

Novosibirskij Institut Bioorganicheskoj Khimii So Ran

METHOD OF SYNTHESIS OF BIOTIN 2-NITRO-4-SULFOPHENYL ESTER SODIUM SALT Russian patent published in 1998 - IPC

Abstract RU 2102395 C1

FIELD: organic chemistry. SUBSTANCE: biotin 2-nitro-4-sulfophenyl ester sodium salt is synthesized by interaction of 2-nitro-4-sulfophenol sodium salt with biotin in medium of dimethylformamide in the presence of dicyclohexylcarbodiimide. Biotin and dicyclohexylcarbodiimide were added to reaction medium by batches up to mole ratio of the indicated reagents with respect to salt = 1:(1.4-1.6):(1.3-1.5), respectively. Invention can be used in bioorganic chemistry and molecular biology for synthesis of oligo(poly)nucleotides and biologically active proteins carrying biotin group. EFFECT: improved method of synthesis.

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RU 2 102 395 C1

Authors

Beklemishev A.B.

Pichko N.P.

Karjagin A.Ju.

Dates

1998-01-20—Published

1996-01-24—Filed

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