INDOLE DERIVATIVES AND PHYSIOLOGICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF, METHODS OF PREPARING THEREOF, DRUG FOR TREATMENT OR PROPHYLAXES OF CLINICAL STATES FOR WHICH ADMINISTRATION OF 5-HT-LIKE RECEPTOR AGONIST, AND METHOD OF PREPARING THEREOF Russian patent published in 2000 - IPC

Abstract RU 2160736 C2

FIELD: medicine. SUBSTANCE: described are indole derivatives of formula I: wherein n is integer of 1 to 3, W is group of formula (i), (ii) or (iii) wherein R is hydrogen or C1-4 alkyl; X is -O-or - NH; Y is O or S; chiral center in formula (i) or (ii) is in (S) or (R) form or mixture thereof in any ratios; Z denotes groups of formula -CH2CH2NR1R2, V or VI , R1, R2 and R3 are hydrogen or C1-4 alkyl; and physiologically acceptable salts or solvates thereof provided that compound N,N-dimethyl-2-[5-(2-oxo-1,3-oxazolidin-4-yl- methyl)-1H-indol-3-yl)ethylamine is deleted. Indole derivatives of formula I are useful in prophylaxis of clinical states for which administration of "5-HT1- like receptor agonist is recommended. Also described are method of preparation thereof, drug based on indole derivatives of formula I and method of preparing drug. EFFECT: improved properties of the drug and more efficient preparation method thereof. 18 cl, 13 tbl

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RU 2 160 736 C2

Authors

Alan Dunkan Robertson

Alan Piter Khill

Robert Charl'Z Glen

Grem Richard Martin

Dates

2000-12-20Published

1991-06-06Filed