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2 108 337

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IPC

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Application

95100477/04, 1995-01-10

(22)

Actual filing date

1995-01-10

(45)

Published

1998-04-10

(72)

Inventor

Mjasoedov N.F.Shevchenko V.P.Faradzheva S.V.Nagaev I.Ju.

(73)

Holder

Institut Molekuljarnoj Genetiki Ran

METHOD OF SYNTHESIS OF 4-ETHYL-2,6,7-TRIOXA-1-PHOSPHOBICYCLO-[2,2,2]-OCTANE-1-OXIDE HIGHLY LABELED WITH TRITIUM OR DEUTERIUM AT ETHYL RADICAL Russian patent published in 1998 - IPC

Abstract RU 2108337 C1

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to new substance - 4-ethyl-2,6,7-trioxa-1-phosphobicyclo-[2.2.2]-octane-1-oxide highly labeled with tritium or deuterium at ethyl radical. The parent compound is subjected for reaction of catalytic solid-phase heterogeneous isotope exchange between substance hydrogens and gaseous tritium. Reaction of isotope exchange is carried out for 15-25 min at 160-180 C using 5% Pt/C as a catalyst. Ratio of catalyst and substance = (8-12):1. Synthesized compound can be used in chemistry of physiologically active compounds in medical-biological investigations. EFFECT: improved method of synthesis.

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RU 2 108 337 C1

Authors

Mjasoedov N.F.

Shevchenko V.P.

Faradzheva S.V.

Nagaev I.Ju.

Dates

1998-04-10—Published

1995-01-10—Filed

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