CYCLOPEPTIDE OR ITS PHARMACEUTICALLY ACCEPTABLE SALT, METHODS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1998 - IPC

FIELD: organic chemistry, peptides. SUBSTANCE: product: cyclopeptides of the formula (I): where: R¹ - hydrogen or acyl; R² - hydroxy- or acylhydroxy-group; R³ - hydroxysulfonyloxy-group; R⁴ - carbamoyl at condition that R¹ can not be palmitoyl when R² - hydroxy and R³ - hydroxysulfonyloxy-group, or their pharmaceutical salts; methods of their synthesis: (a) by R¹-group splitting off; (b) synthesis of compound of the formula (I) where R¹ - acyl by (I) acylation where R¹ - H; (c) by synthesis of (I) where R¹ - ap-(lower)-alkanoyl by amino-groups deblocking and d) synthesis of compounds of the formula (I) where R¹ - pyridyl-thio-(lower)-alkanoyl by interaction of (I) where R¹ - halogen-(lower)-alkanoyl with pyridine-thione; (e) synthesis of (I) where R^l - acyloxy by acylation of (I) where R² - hydroxy-group; pharmaceutical composition showing antimicrobial activity and containing (I) as an active component taken at effective amount. Synthesized compounds are used in medicine. EFFECT: improved method of synthesis. 8 cl, 4 tbl