FIELD: organic chemistry; pharmaceutics. SUBSTANCE: stereoselective synthesis of alkylated hydroxyindole resides in reacting racemic-grade hydroxyindole with halogenated acetonitrile under interphase transfer reaction conditions, in presence of chiral catalyst. Mixture of enantiomers is subjected to separation by recrystallization in suitable solvent. EFFECT: higher efficiency. 4 cl, 2 tbl
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| METHOD FOR STEREOSELECTIVE PRODUCTION OF ASYMMETRICAL DERIVATIVES OF OXINDOLE |
1991 |
- Tomas Bing Kin Li[Us]
- Dzhordzh S.K. Vong[Us]
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| CARBAMIC ACID DERIVATIVES AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, METHOD OF THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1992 |
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| METHOD OF SYNTHESIS OF AMINOCARBONYLCARBAMATES |
1990 |
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- Rassel Richard Li Khejmer[Us]
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RU2069664C1 |
| GALANTAMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION |
1994 |
- Rajmond V.Koslej
- Larri Dehvis[Us]
- Veronika Taberna[Uy]
|
RU2109743C1 |
| METHOD OF SYNTHESIS OF HEXAHYDRO-8-METHYLPYRROLO[2,3-B]-INDOLE COMPOUNDS |
1993 |
- Dzhordzh S.K.Vong[Hk]
- Tomas B.K. Li[Us]
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RU2108334C1 |
| METHOD OF SYNTHESIS OF PHYSOSTIGMINE DERIVATIVES (VARIANTS) |
1993 |
- Dzhordzh E.Lii
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- Donna M.Borek
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RU2116307C1 |
| GALANTHAMINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION |
1994 |
- Rajmond V.Koslej
- Larri Dehvis
- Veronika Taberna
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RU2114850C1 |
| 1-[PYRIDO(3,4-B)-1,4-OXAZINYL-4-YL]-1H-INDOLES, METHOD OF THEIR SYNTHESIS, COMPOSITION ON THEIR BASIS AND DERIVATIVE OF N-(4-PYRIDINYL)-1H-INDOLE-1-AMINE |
1992 |
- Richard Charl'Z Ehffland[Us]
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RU2042680C1 |
| [(ARYLALKYLPIPERIDINYL-4-YL)-METHYL]-2A,3,4,5-TETRAHYDRO-1-ONES OR THEIR ACID-ADDITIVE SALTS AND A METHOD OF THEIR PREPARING |
1992 |
- Rehjmond V.Kosli Ml.[Us]
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| METHOD OF SYNTHESIS OF N-ETHYLHYDROXYLAMINE HYDROCHLORIDE AND METHOD OF SYNTHESIS OF N,O-BIS-[(1,1-DIMETHYLETHOXY)CARBONYL]-HYDROXYLAMINE |
1992 |
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RU2078078C1 |
