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2 139 292

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IPC

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Application

98106319/04, 1998-04-07

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Start date

1998-04-07

(22)

Actual filing date

1998-04-07

(45)

Published

1999-10-10

(72)

Inventor

Rzheznikov V.M.Golubovskaja L.E.Minajlova O.N.Smirnova Z.S.Osetrova I.P.Sushinina L.P.Titova T.A.Tolkachev V.N.

(73)

Holder

Onkologicheskij Nauchnyj Tsentr Im.N.N.Blokhina RamnEhndokrinologicheskij Nauchnyj Tsentr Ramn

3-OR-DI-(2-CHLOROETHYL)-AMINO-CONTAINING II α-ACYL-(HYDR)- -OXYSTEROIDS SHOWING ANTITUMOR ACTIVITY Russian patent published in 1999 - IPC

Abstract RU 2139292 C1

FIELD: organic chemistry, steroids. SUBSTANCE: invention relates to 3-OR- -di-(2-chloroethyl)-amino-containing II α--acyl(hydr)oxy-steroids of the general formula (I) α- where: R is ; COCH₂C₆H₄N(CH₂CH₂Cl)₂ is R₁ + β-OCOCH₃; α-C≡CH; + β-OCOC₂H₅-H; α is H, R₂ showing an antitumor activity. Invention describes new types of antitumor compounds showing cytotoxic and an antiestrogenic effect and cytotoxic compounds no eliciting an adverse estrogenic effect. EFFECT: new compounds showing an antitumor activity. 2 tbl, 4 ex

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RU 2 139 292 C1

Authors

Rzheznikov V.M.

Golubovskaja L.E.

Minajlova O.N.

Smirnova Z.S.

Osetrova I.P.

Sushinina L.P.

Titova T.A.

Tolkachev V.N.

Dates

1999-10-10—Published

1998-04-07—Filed