METHOD OF PREPARING 2,6-DICHLORO-5-FLUORONICOTINIC ACID AND CHLORIDE THEREOF Russian patent published in 1998 - IPC

Abstract RU 2114831 C1

FIELD: chemical industry. SUBSTANCE: present invention describes method of preparing 2,6-dichloro-5-fluoronicotinic acid and chloride thereof of formula (I): by chlorination of substituted 2,6-dihydroxypyridine derivative of formula II: with phosphorus oxychloride in the presence of lithium salt on heated followed by cooling of reaction mixture, dilution with diluent and recovery of chlorination product of formula . In order to prepare product (I) wherein R is hydroxyl, said product is reacted with base in the presence of water followed by extraction of the resulting solution with solvent and neutralization with acid. Process proceeds without formation of by-products and with good yield. EFFECT: more efficient preparation method. 10 cl, 3 ex

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RU 2 114 831 C1

Authors

Reks Ehllen Dzhennings

Dates

1998-07-10Published

1993-07-19Filed