FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: invention relates to the synthesis of compounds showing antagonistic activity with respect to endothelin. Invention relates to also sulfonamide derivatives of the formula (I) 
where one of X or Y is N-atom and another one is O-atom; R - naphthyl or substituted naphthyl; R4 and R5 - radicals given in description, and their pharmaceutically acceptable salts also. EFFECT: improved method of synthesis. 15 cl, 64 ex
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