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2 407 740

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IPC

C07D265/14(2006-01-01)

C07D265/36(2006-01-01)

C07D279/16(2006-01-01)

C07D413/12(2006-01-01)

C07D417/12(2006-01-01)

A61K31/535(2006-01-01)

A61K31/54(2006-01-01)

A61P3/00(2006-01-01)

(21) (22)

Application

2008136572/04, 2007-02-02

(24)

Start date

2007-02-02

(22)

Actual filing date

2007-02-02

(45)

Published

2010-12-27

(72)

Inventor

Akermann ZhanBlajkher KonradChekkarelli Simona M.Shom'Enn Odil'Mattej PatritsioObst Sander Ul'Rike

(73)

Holder

F.Khoffmann-Lja Rosh Ag

HETEROBICYCLIC SULPHONAMIDE DERIVATIVES FOR TREATING DIABETES Russian patent published in 2010 - IPC C07D265/14 C07D265/36 C07D279/16 C07D413/12 C07D417/12 A61K31/535 A61K31/54 A61P3/00

Abstract RU 2407740 C2

FIELD: chemistry.

SUBSTANCE: described are heterobicyclic derivatives of formula (I)

, in which V denotes -C(R⁷)-; W denotes a single bond or -C(R⁸R⁹)-; X denotes O, S, SO, SO₂ or N(R¹⁰); Y denotes -C(R¹¹R¹²)-, -C(R¹¹R¹²)C(R¹³R¹⁴)C(R¹¹R¹²)C(R¹³R¹⁴)C(R¹⁵R¹⁶)-, -C(R¹¹R¹²)C(R¹³R¹⁴)C(R¹⁵R¹⁶)C(R¹⁷R¹⁸)- or- C(R¹¹)=C(R¹²)-; R¹, R², R³, R⁴ and R⁵ independently denote hydrogen, halogen, (lower)alkyl, fluoro(lower)alkyl, (lower)alkoxy group, fluoro(lower)alkoxy group, NH₂-C(O); R⁶ denotes a phenyl, pyridyl, pyrazolyl or thiazolyl group, where the group is optionally substituted with 1-4 substitutes selected from a group consisting of halogen, cyano group, (lower)alkyl, (lower)alkoxy group, COOH, 1H-tetrazol-5-yl, 5-oxo-4H-[1,2,4]oxadiazol-3-yl, where (lower)alkyl is optionally substituted with COOH. A pharmaceutical composition is also described.

EFFECT: said compounds inhibit L-CPT1 and can be used as medicinal agents.

27 cl, 120 ex

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RU 2 407 740 C2

Authors

Akermann Zhan

Blajkher Konrad

Chekkarelli Simona M.

Shom'Enn Odil'

Mattej Patritsio

Obst Sander Ul'Rike

Dates

2010-12-27—Published

2007-02-02—Filed