FIELD: medicine, vaccines. SUBSTANCE: invention relates to vaccine composition involving antigen, 3-de-O-acylated monophosphoryllipid-A and QS-21 as an adjuvant. This composition shows property to cause cytolytic T-cellular response in mammals. Invention relates to a method of preparing this vaccine by mixing antigen with 3-de-O-acylated monophosphoryllipid-A in an aqueous suspension followed by addition of QS-21 in an aqueous solution with sodium chloride at pH 6.5 ± 0.5. Vaccine composition shows property to induce the broadened pattern of immune responses as compared with the known ones. EFFECT: enhanced effectiveness of vaccine composition. 8 cl, 3 ex, 2 tbl
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