FIELD: medicine. SUBSTANCE: invention proposes a new vaccine preparation for treatment and prophylaxis of hepatitis infection, especially hepatitis B, that consists of hepatitis antigen and acceptable carrier, for example, aluminate with 3-O-deacylated monophosphoryl-lipid A. Invention describes the mixed vaccines involving the indicated vaccine preparation and a method of prophylaxis of hepatitis. Vaccine preparation is effective with respect to making protective response being at very low doses of antigen. EFFECT: enhanced effectiveness of vaccine composition. 14 cl, 8 tbl, 7 ex
Authors
Dates
1998-11-20—Published
1993-03-24—Filed