DERIVATIVES OF THIAZOLIDINE, PHARMACEUTICAL COMPOSITION SHOWING HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY AND INHIBITING ACTIVITY OF ALDOSE REDUCTASE, AND A METHOD OF TREATMENT AND PROPHYLAXIS OF DISEASES IN MAMMALS Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: invention proposes derivatives of thiazolidine of the formula (I) where R¹ and R² are similar of different and each means hydrogen, alkyl with 1-8 carbon atoms; R³ - hydrogen; A and B are similar or different and each means hydrogen or alkyl with 1-8 carbon atoms, or A-B - groups: -C=O, =C=S, -CH₂-CH₂-; X - group W-(CH₂)_m-X′ where W - phenyl that can be unsubstituted or substituted with at least a single substituent taken from alkyl with 1-4 carbon atoms, alkoxy-group with 1-4 carbon atoms, halogen, phenyl and group -NR^a-R^b where R^a and R^b are similar or different and each means hydrogen or alkyl with 1-8 carbon atoms; X¹ - a single bond, oxygen, sulfur or group NR⁴ where R⁴ - alkyl with 1-8 carbon atoms; m = 0-8; Y - group of the formula -(CH₂)_n-Y′- where Y′ - oxygen, sulfur; n = 1-5; Z - group of the formula (II) , and their salts. Invention proposes pharmaceutical composition containing compound of the formula (I) and a method of treatment and prophylaxis of diseases in mammals with compounds showing HYPOGLYCEMIC and hypolipidemic activity. Synthesized compounds decrease blood glucose and triglycerides levels. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 28 cl, 10 tbl, 122 ex