AZAANTRACYCLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

Abstract RU 2159245 C2

FIELD: synthesis of biologically-active compounds. SUBSTANCE: invention provides novel azaantracycline derivatives of general formula I: (I), in which X1 and X2 are CO groups; X3 group CO, CHOH, or C = N(R9), wherein R9 is hydroxy group; R1, R2 and R3 are hydrogen atoms; R4 hydrogen or C1-C6-alkoxy; R5 and R8 are hydroxy groups; R6 is hydrogen or group Rв-CH2, wherein Rв is phenyl optionally substituted by C1-C6-alkoxy group, pyridinyl, or group Rc-CH=CH-, wherein Rc is hydrogen atom; and R7 is methyl, and also their pharmaceutically acceptable salts. Compounds I can be used in treatment of amyloidosis. EFFECT: enlarged assortment of therapeutically important agents. 5 cl, 1 tbl, 20 ex

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RU 2 159 245 C2

Authors

Mikele Karuzo

Daniela F'Jardi

Titsiano Band'Era

Zhaklin Lansen

Antonio Suarato

Dates

2000-11-20Published

1996-07-23Filed