PHARMACEUTICAL COMPOSITIONS OF 3-SUBSTITUTED 2-HYDROXYINDOLE-1-CARBOXAMIDES, METHOD OF INHIBITION OF COLLAGENASE ACTIVATION, METHOD OF INDUCING ANALGETIC RESPONSE, METHOD OF TREATMENT OF PATIENTS WITH INFLAMMATORY SICKNESSES Russian patent published in 1998 - IPC

FIELD: organic chemistry. SUBSTANCE: pharmaceutical composition has: A) at least one triglyceride or propylene glycolic ester of fatty acids from fractionated coconut oil; and B) at least one compound of the formula (I): where R₁, R₂ and R₃ each means independently hydrogen, fluorine, bromine or chlorine, or its pharmaceutically acceptable salt. Invention proposes also methods of inhibition of collagenase activity, inducing analgetic response and treatment of patients with inflammatory sicknesses by administration of composition at effective amount and therefore can be used in medicine. EFFECT: improved safety, prolonged fitness time. 19 cl, 4 ex, 2 tbl