FIELD: medicine, pharmacology. SUBSTANCE: method involves binding in vivo molecule-carriers of parmacoactive compounds with blood cells taking part in pathological process. For this binding original derivatives of pharmacological agents and RvD-containing peptide are synthesized. Pharmacological agent bound to RvD-peptide and administrated in circulatory system is able to bind with platelet 2b/3a-receptors and transported by cells to places with increased platelet adhesion (atherosclerotic damages of blood vessels, metastatic zones of tumor proliferation and other points of platelet cluster). Method ensures to reach high concentration of preparation in damage focus for necessary time interval. EFFECT: improved method of drug delivery. 1 tbl, 2 dwg
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Authors
Dates
1998-09-27—Published
1996-01-05—Filed