MODULE MOLECULAR CONJUGATE FOR TARGETING GENETIC CONSTRUCTS AND METHOD FOR PREPARING IT Russian patent published in 2014 - IPC C07K7/23 C07K5/11 C07K7/06 A61K38/09 A61P5/02 A61P35/00 

Abstract RU 2529034 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine and veterinary science, and can be used as an effective agent for the targeted delivery of DNA complexes with molecular conjugates into certain mammalian organs and tissues. The declared invention considerably improves the efficiency of the DNA delivery into the tumour cells and substantially simplifies, reduces the prices and time of molecular conjugate synthesis by using a module-based approach, as well as by providing a possibility of rapid alternation of ligand components for varying a conjugate affinity to various tumour and normal body cells.

EFFECT: invention enables correcting the problem of tumour disease gene therapy, as the prepared module peptide conjugate is as shown by multiple real-time tests an effective agent for the targeted delivery, and most significantly, non-toxic, immunogenic and causes no side effects.

2 cl, 7 dwg, 10 ex

Similar patents RU2529034C2

Title Year Author Number
MOLECULAR CONJUGATE ON BASIS OF SYNTHETIC ANALOGUES OF LULIBERIN AND APPLICATION THEREOF AS DNA DELIVERY SYSTEM TO CELLS OF HORMONE-SENSITIVE TUMOURS (VERSIONS) 2007
  • Burov Sergej Vladimirovich
  • Jablokova Tat'Jana Viktorovna
  • Orlov Sergej Vladimirovich
  • Perevozchikov Andrej Petrovich
RU2377247C2
MOLECULAR CONJUGATES WITH POLYCATIONIC SECTION AND LIGAND FOR DELIVERY OF DNA AND RNA INTO CELL AND CELL NUCLEUS 2009
  • Burov Sergej Vladimirovich
  • Ivanov Igor' Al'Bertovich
  • Orlov Sergej Vladimirovich
RU2537262C2
LABELLED DENDRIMER PEPTIDES 2016
  • Andreev Sergej Mikhajlovich
  • Shilovskij Igor Petrovich
  • Sundukova Mariya Sergeevna
  • Maerle Artem Vladimirovich
  • Sergeev Ilya Viktorovich
RU2611399C1
MEAN FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS TO CELLS OF MAMMALS 2014
  • Andreev Sergej Mikhajlovich
  • Chupina Nina Anatol'Evna
  • Shilovskij Igor' Petrovich
  • Khaitov Musa Rakhimovich
RU2572575C1
VECTOR POLYPEPTIDE ANALOG OF TRANSFORMING GROWTH FACTOR ALPHA (TGF) FRAGMENT, ITS ANTITUMOR CONJUGATE AND PHARMACEUTICAL COMPOSITION ON CONJUGATE BASE 2004
  • Zakharova Ivetta Vladimirovna
  • Kiselev Sergej Mikhajlovich
  • Lutsenko Elena Valer'Evna
  • Lutsenko Sergej Viktorovich
  • Makarov Vladimir Alekseevich
  • Severin Evgenij Sergeevich
  • Severin Sergej Evgen'Evich
  • Fel'Dman Natalija Borisovna
RU2277930C1
IMPROVED POLYETHYLENIMINE POLYETHYLENE GLYCOL VECTORS 2015
  • Levitski Aleks
  • Dzhubran Salim
  • Shir Aleksej
  • Zigler Majya
  • Talkhami Alaa
  • Langut Yael
RU2771104C2
POLY-LIGAND MEDICINAL CONJUGATES AND USE THEREOF 2016
  • Huang, Baohua Robert
  • Dai, Jian
  • Wang, Zhongbo
  • Xie, Xueyuan
  • Liu, Xiaodong
  • Hu, Xinli
RU2722449C2
PEPTIDE VECTORS 2004
  • Dong Chzhen Ksin
  • Shen Jilana
  • Komstok Dzhinn Mehri
  • Kim San Kh.
RU2361876C2
PEPTIDE VECTOR, METHOD FOR ITS PREPARING, NUCLEOTIDE SEQUENCE, RECOMBINANT PLASMID DNA AND STRAIN ESCHERICHIA COLI B-8389 VKPM FOR ITS PREPARING, METHOD FOR GENETIC MODIFICATION OF MAMMALIAN AND HUMAN CELLS 2003
  • Pozmogova G.E.
  • Chuvilin A.N.
  • Posypanova G.A.
  • Shul'Ga A.A.
  • Ehl'Darov M.A.
  • Ermoljuk Ja.S.
  • Severin E.S.
  • Kirpichnikov M.P.
  • Skrjabin K.G.
RU2248983C1
PEPTIDES FOR INTRACELLULAR DELIVERY OF NUCLEIC ACIDS 2020
  • Khaitov Musa Rakhimovich
  • Kozhikhova Kseniya Vadimovna
  • Koloskova Olesya Olegovna
  • Andreev Sergej Mikhajlovich
  • Timofeeva Anastasiya Vitalevna
  • Shatilov Artem Andreevich
  • Shilovskij Igor Petrovich
  • Kofiadi Ilya Andreevich
  • Smirnov Valerij Valerevich
  • Nikonova Aleksandra Aleksandrovna
RU2771605C2

RU 2 529 034 C2

Authors

Burov Sergej Vladimirovich

Orlov Sergej Vladimirovich

Leko Marija Viktorovna

Perevozchikov Andrej Petrovich

Chelushkin Pavel Sergeevich

Dates

2014-09-27Published

2012-12-28Filed