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2 473 559

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IPC

C07K14/46(2006-01-01)

A61K38/17(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2011143065/04, 2011-10-26

(24)

Start date

2011-10-26

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Actual filing date

2011-10-26

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Published

2013-01-27

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Inventor

Utkin Jurij NikolaevichZhmak Maksim NurgajanovichAndreeva Tat'Jana ViktorovnaVajze KristofKrjukova Elena ViktorovnaTsetlin Viktor IonovichKasheverov Igor' Evgen'EvichStarkov Vladislav Gennad'Evich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju

PEPTIDE AZEMYOPSYN SELECTIVELY REACTING WITH NICOTINE MUSCARINIC RECEPTORS AND APPLICABLE AS MYORELAXANT IN MEDICINE AND COSMETOLOGY Russian patent published in 2013 - IPC C07K14/46 A61K38/17 A61P25/00 

Abstract RU 2473559 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to nicotinic acetylcholine receptor blocking biologically active peptides which can find application in biochemistry, biotechnology and medicine. The peptide azemyopsin has an amino acid sequence: H2N-Asp1-Asn2-Trp3-Trp4-Pro5-Lys6-Pro7-Pro8-His9-Gln10-Gly11 Pro12-Arg13-Pro14-Pro15-Arg16-Pro17-Arg18-Pro19-Lys20-Pro21-COX wherein X is a group OH or NH2, and has an ability to react selectively with nicotine muscarinic receptors. The peptide may be used an a base for preparing myorelaxants selectively blocking muscarinic receptors.

EFFECT: invention presents a new type of natural toxins reacting with nicotine receptors and containing no disulphide bonds.

2 cl, 5 dwg, 1 tbl, 4 ex

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RU 2 473 559 C1

Authors

Utkin Jurij Nikolaevich

Zhmak Maksim Nurgajanovich

Andreeva Tat'Jana Viktorovna

Vajze Kristof

Krjukova Elena Viktorovna

Tsetlin Viktor Ionovich

Kasheverov Igor' Evgen'Evich

Starkov Vladislav Gennad'Evich

Dates

2013-01-27—Published

2011-10-26—Filed

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