FIELD: medicine. SUBSTANCE: present invention describes novel compounds of formula (I): 
wherein Y is CH2 or CO; R1 is F, Cl or OH; R2 is H, F or Cl and R3 is H, CH3 or CH2CH3, except for 4-(5-chloro- 2,3-dihydro-1H-inden-2-yl)-1H-imidazole and 4-(4-chloro- 2,3-dihydro-1H-indan-2-yl)-1H-imidazole, and non-toxic acid addition salts and mixtures thereof. The present invention describes methods of preparing said compounds and also novel pharmaceutical compositions comprising at least on compound from among said compounds or salts thereof. Compounds and non-toxic salts thereof have useful pharmacological activity and are highly selective and long acting α2-andrenoreceptor antagonists. Peroral activity is adequate. Compounds are especially useful for treating cognition ability disorders. EFFECT: improved properties of the pharmaceutical composition. 28 cl, 11 ex, 3 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE OR ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT | 1990 |
|
RU2021263C1 |
| IMIDAZOLE DERIVATIVES, METHOD FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF AND METHOD FOR TREATMENT BY THEIR USING | 2001 |
|
RU2265598C2 |
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLE | 1992 |
|
RU2045519C1 |
| SUBSTITUTED 4(5)-IMIDAZOLES OR THEIR NONTOXIC PHARMACEUTICALLY ACCEPTABLE SALTS WITH ACIDS | 1991 |
|
RU2036193C1 |
| METHOD OF SYNTHESIS OF SUBSTITUTED IMIDAZOLES OR THEIR PHARMACEUTICAL ACCEPTABLE ACID ADDITIVE SALTS | 1991 |
|
RU2067578C1 |
| METHOD FOR OBTAINING SUBSTITUTED IMIDAZOLE OR ITS NONTOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT | 0 |
|
SU1836355A3 |
| DERIVATIVES OF IMIDAZOLE AND PHARMACEUTICALLY ACCEPTABLE COMPOSITION | 1996 |
|
RU2188194C2 |
| METHOD OF PRODUCING SUBSTITUTED DERIVATIVES OF IMIDAZOLE OR THEIR NON-TOXIC ADDITIVE SALTS WITH ACIDS | 0 |
|
SU1424736A3 |
| ADMINISTRATION OF ATIPAMEZOLE FOR TREATING SEXUAL MALE IMPOTENCE | 1992 |
|
RU2111749C1 |
| METHOD OF OBTAINING DERIVATIVES OF SUBSTITUTED IMIDAZOLE AND INTERMEDIATE COMPOUNDS, USED IN METHOD | 2004 |
|
RU2329253C2 |
