METHOD OF OBTAINING DERIVATIVES OF SUBSTITUTED IMIDAZOLE AND INTERMEDIATE COMPOUNDS, USED IN METHOD Russian patent published in 2008 - IPC C07D233/54 

FIELD: chemistry.

SUBSTANCE: invention pertains to the method of obtaining derivatives of substituted imidazole with general formula (I) and their acid-additive salts, where Y represents -CH₂- or -CO-, R₁ represents H, halogen or hydroxyl, R₂ represents H or halogen, and R₃ represents H or low alkyl. The method involves the following stages: a) halogenation of formula II compound, in which Y, R₁ R₂ and R₃ assume values given above, with use of formula III compound, in which Y, R₁ R₂ and R₃ assume values give above, and X represents a halogen atom, b) reaction of the obtained formula III compound with an amine with formula R₄NH₂, in which R₄ represents an easily removable leaving group, and thiocyanate of an alkaline metal with obtaining of formula IV compound, in which Y, R₁ R₂, R₃ and R₄ assume the values given above, c) removal of the mercapto group from the formula IV compound with obtaining of formula V compound, in which Y, R₁ R₂, R₃ and R₄ assume values give above, d) removal of R₄ group from formula V compound with obtaining of formula I compound, and if desired, e) conversion of the obtained formula I compound to its acid-additive salt. The invention also relates to intermediate compounds and the method of obtaining them.

EFFECT: method of obtaining formula I compound with good output and large-scale process.

20 cl, 6 ex