POLYPEPTIDE DERIVATIVES, METHOD OF CALCIUM CHANNEL INHIBITION Russian patent published in 1998 - IPC

FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: invention relates to derivatives of polypeptides of the general formula (I): where A: A₁-A₄ is Leu-Phe-Glu-Cys-Cys-Leu-Gly- -Glu-; Cys-Ala-Glu-Phe-; Ser-Cys-Gly-His-; Leu-Ile-Glu-Cys-; A₅ is Ala, Val, Gln, Asn; B: B₆-B₉ is Leu-Ser-Cys-Asp-; Ser-Lys-Cys-Lys-; Gly-Thr-Pro-Cys-; Val-Pro-Cys-Asp-; Phe-Ser- -Cys-Asp-; B₁₀ is Ile, Lys, Glu; C: C₁₁-C₁₄ is Lys-Lys-Asn-Gly-; Asp-Ser-Gly-Cys-; Lys-Asn-Trp-Asp-; Thr-Lys-Asn-Gly-; Asp-Arg-Pro-Asn; C₁₅ is Lys, Cys; D: D₁₆-D₁₉ is Pro-Cys-Lys-Pro-; Gly-Thr-Leu-Glu-; Cys-Lys-Gly-Lys-; Cys-Ser-Lys-Thr-; D₂₀ is Cys, Val, Gly, Lys; E: E₂₁-E₂₄ is Gly-Glu-Lys-Lys-; Ser-Pro-Thr- -Trp-; Cys-Leu-Glu-Pro-; E₂₅ is Cys, Lys, Trp, Thr; F: F₂₆-F₃₀ is Ser-Gly-Gly-Trp-; Trp-Cys-Val-Tyr-; Lys-Leu-Cys-Ala-; Gly-Tyr- -Gly-Arg; F₃₀ is Arg, Cys, Pro, Tyr; G: G₃₁-G₃₄ is Cys-Lys-Ile- -Asn-; Ser-Pro-Phe-; Glu-Ser-Pro-Phe-; Tyr-Ala-Ser-Tyr-; Cys-Leu-Lys-Val-; G₃₅ is Phe, Tyr, simple bond; Z is OH, Cys- -Leu-Lys-Val-OH, Cys-Leu-Ile-OH; Ser-Tyr-Lys-Thr-Leu-OH being six cysteine residues in compound (I) are bound by disulfide bonds. Method of inhibition of calcium channel involves administration of polypeptide in cell at effective amount. Invention can be used in medicine for treatment of mammals with sicknesses mediated by calcium channels. EFFECT: simplified method, enhanced effectiveness of method. 3 cl, 9 ex, 9 tbl