CYCLIC PEPTIDES OR THEIR ADDITIVE ACID SALTS, A COMPOSITION SHOWING ANTIFUNGAL AND ANTIPNEUMOCYSTOSIS ACTIVITY, A METHOD OF TREATMENT OF PATIENTS WITH FUNGAL INFECTIONS Russian patent published in 1998 - IPC

FIELD: organic chemistry, chemistry of peptides. SUBSTANCE: invention relates to some azacyclohexapeptide compounds with nitrogen atom that is bound to cyclohexapeptide ring at 5-th carbon atom of component 4-hydroxyornithine of the formula (I) where R₁ is H or OH; R₂ is H, CH₃ or OH; R₃ is H, CH₃, CH₂CN, CH₂CH₂NH₂ or CH₂CONH₂; R¹ is C₉-C₂₁-alkyl, C₉-C₂₁-alkenyl, C₁-C₁₀-alkoxyphenyl or C₁-C₁₀-alkoxynaphthyl; R^II is H, C₁-C₄-alkyl, C₃-C₄-alkenyl, (CH₂)_2-4-OH, CO(CH₂)_1-4-NH₂, (CH₂)_2-4-NR^IVR^V; R^II and R^III taken together are ; R^IV is H or alkyl; R^V is H or alkyl, and their additive salts. Compounds (I) are active against many fungi, in part, against species Candida. Synthesized compounds can be used also for inhibition or relief of infectious sicknesses course caused by Pneumocystis carini in patients with decreased immunity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 11 cl, 10 tbl, 31 ex