FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new derivatives of piperazinylpentamide of the formula (I) 
which inhibit activity of protease encoded by human immunodeficiency virus. Invention describes also a pharmaceutical composition based on compound of the formula (I) that is used for inhibition of HIV-infection. EFFECT: enhanced effectiveness. 13 cl, 4 tbl, 17 ex
| Title |
Year |
Author |
Number |
| COMBINATION OF HIV-PROTEASE INHIBITOR WITH OTHER ANTIVIRAL COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON SAID AND METHOD OF PHARMACEUTICAL COMPOSITION PREPARING |
1994 |
- Dzhozef P.Vakka
- Dzhejms P.Gar
- Brjus D.Dorsi
- M.Katarin Khollouehj
- Rehndall V.Khangejt
|
RU2139052C1 |
| METHOD OF PREPARING PIPERAZINYL PENTANEAMIDE AND PIPERAZINYL PENTANEMIDE DERIVATIVE |
1992 |
- Vakka Dzhozef P.
- Dorsi Brjus D.
- Guar Dzhejms P.
- Khollovej Katrin M.
- Khangejt Rehndell V.
|
RU2171254C2 |
| INHIBITORS OF HIV-PROTEASE |
1994 |
- Dzhoel R.Khaff
- Dzhozef P.Vakka
- Brjus D.Dorsi
|
RU2137768C1 |
| INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF HIV-PROTEASE INHIBITORS AND A METHOD OF THEIR SYNTHESIS |
1994 |
- Dehvid Askin
- Ral'F P.Volante
- Kehn K.Eng
|
RU2125561C1 |
| METHOD OF SYNTHESIS OF INTERMEDIATE COMPOUNDS USED FOR SYNTHESIS OF HIV-PROTEASE INHIBITORS |
1994 |
- Dehvid Askin
- Pol' Rejder
- Kaj Rossen
- Richard Dzh.Varsolona
- Kennet M.Uehlls
|
RU2134263C1 |
| COMBINATION OF INHIBITORS OF HIV-PROTEASE |
1995 |
- Dojch Pol Dzh.
- Ehmini Ehmilio A.
- Vehkka Dzhozef P.
|
RU2194506C2 |
| METHOD OF RACEMIZATION OF OPTICALLY PURE OR ENRICHED PIPERAZIN-2-TERT-BUTYLCARBOXAMIDE SUBSTRATE AND RACEMIC 2-TERT-BUTYLCARBOXAMIDE-4-(3-PICOLYL)PIPERAZINE |
1995 |
- Kaj Rossen
- Dehvid Askin
- Pol Rejder
- Richard Dzh.Varsolona
- Ral'F Volante
|
RU2135482C1 |
| BENZOXAZINONES AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF FOR INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, TREATMENT AND PROPHYLAXIS OF AIDS AND ARS, METHOD OF INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, METHOD OF PROPHYLAXIS OF HIV INFECTION, TREATMENT OF HIV AND ARS, COMBINATIONS, METHOD OF SYNTHESIS OF (-)-6-CHLORO- -4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4- -DIHYDRO-2H-3,1-BENZOXAZINE-2-ONE |
1993 |
- Jang Stiven D.
- Britcher Sjuzn F.
- Pejn Linda S.
- Tran Likkhan O.
- Lamma Vill'Jam K. Ml.
|
RU2186775C2 |
| METHOD FOR TREATING RETROVIRUS INFECTION IN MAMMALIAN |
1995 |
- Martin L. Brajant
- Karen E. Potts
- Mehri Smidt
- Simon P. Taker
|
RU2166317C2 |
| COMPOUND, PHARMACEUTICAL COMPOSITION AND METHOD OF INHIBITION OF HIV-PROTEASE ACTIVITY |
1994 |
- Dressmen Brjus Eh.
- Khehmmond Marliz
- Kehldor Stiven U.
- Manrou Dzhon Eh.
- Tehtlok Dzhon Kh.
- Rodriges Majkl Dzh.
- Frits Dzhejms Eh.
- Khornbek Vil'Jam Dzh.
- Kehjlish Vinsent Dzh.
- Rajch Zigfird Khajnz
- Sheperd Timoti Eh.
- Dzhangkhajm Luis N.
|
RU2139280C1 |
