FIELD: medicine, virology, pharmacy. SUBSTANCE: invention proposes a combination that involves N-(2/R)-hydroxy-1(S)-indanyl-2(R)-phenylmethyl- -4(S)-hydroxy-5-[1-[4-(3-pyridylmethyl)-2(S)-N′-(tert. - -butylcarbamoyl)]-piperazinyl] -pentaneamide or its pharmaceutically acceptable salt and any compound taken among of 3'-azido-3'-deoxythymidine, 2',3'-dideoxyinosine and 2', 3'-dideoxycytidine. Indicated combination of compounds can be used also as a pharmaceutical composition in combination with a pharmaceutically acceptable carrier for inhibition of HIV-protease activity. EFFECT: realization of the invention. 6 cl, 5 tbl, 17 ex
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|
RU2131416C1 |
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| INHIBITORS OF HIV-PROTEASE | 1994 |
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| METHOD OF RACEMIZATION OF OPTICALLY PURE OR ENRICHED PIPERAZIN-2-TERT-BUTYLCARBOXAMIDE SUBSTRATE AND RACEMIC 2-TERT-BUTYLCARBOXAMIDE-4-(3-PICOLYL)PIPERAZINE | 1995 |
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| METHOD FOR TREATING RETROVIRUS INFECTION IN MAMMALIAN | 1995 |
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| SUBSTITUTED HETEROCYCLES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, PHARMACEUTICAL COMPOSITION FOR BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS, METHOD OF BLOCKADE OF NEUROKININ-1 RECEPTORS IN MAMMALS | 1993 |
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RU2140914C1 |
