FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention describes new compounds of the formula (I) or their pharmaceutically acceptable salts where 
means a stable 8-10-membered bicyclic heterocycle each ring of that can be saturated or unsaturated and indicated heterocycle consists of carbon atoms and 1-3 heteroatoms taken among the group including atoms N, S or O. Indicated heterocycle can be unsubstituted or substituted with halogen atom or lower C1-4-alkyl at condition that 
is not groups (A). Compounds are inhibitors of protease of human immunodeficiency virus. Invention describes also a pharmaceutical composition based on compounds of the formula (I) and a method of inhibition of HIV-protease. EFFECT: new compounds indicated above as protease inhibitors. 14 cl, 2 dwg, 10 ex
| Title |
Year |
Author |
Number |
| COMBINATION OF HIV-PROTEASE INHIBITOR WITH OTHER ANTIVIRAL COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON SAID AND METHOD OF PHARMACEUTICAL COMPOSITION PREPARING |
1994 |
- Dzhozef P.Vakka
- Dzhejms P.Gar
- Brjus D.Dorsi
- M.Katarin Khollouehj
- Rehndall V.Khangejt
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RU2139052C1 |
| DERIVATIVES OF PIPERAZINYLPENTAMIDE AND PHARMACEUTICAL COMPOSITION FOR INHIBITION OF HIV-PROTEASE ACTIVITY |
1992 |
- Dzhozef P.Vakka
- Brjus D.Dorsi
- Dzhejms P.Guar
- Katrin M.Khollovej
- Rehndell V.Khangejt
|
RU2131416C1 |
| METHOD OF PREPARING PIPERAZINYL PENTANEAMIDE AND PIPERAZINYL PENTANEMIDE DERIVATIVE |
1992 |
- Vakka Dzhozef P.
- Dorsi Brjus D.
- Guar Dzhejms P.
- Khollovej Katrin M.
- Khangejt Rehndell V.
|
RU2171254C2 |
| METHOD OF RACEMIZATION OF OPTICALLY PURE OR ENRICHED PIPERAZIN-2-TERT-BUTYLCARBOXAMIDE SUBSTRATE AND RACEMIC 2-TERT-BUTYLCARBOXAMIDE-4-(3-PICOLYL)PIPERAZINE |
1995 |
- Kaj Rossen
- Dehvid Askin
- Pol Rejder
- Richard Dzh.Varsolona
- Ral'F Volante
|
RU2135482C1 |
| INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF HIV-PROTEASE INHIBITORS AND A METHOD OF THEIR SYNTHESIS |
1994 |
- Dehvid Askin
- Ral'F P.Volante
- Kehn K.Eng
|
RU2125561C1 |
| METHOD OF PREPARING EPOXIDE |
1995 |
- Dehvid Askin
- Kehn K.Ehng
- Peter E.Mehligres
- Pol Dzh.Rejder
- Kaj Rossen
- Rol'F P.Volant
- Vina Upadkhaj
|
RU2137769C1 |
| METHOD OF SYNTHESIS OF INTERMEDIATE COMPOUNDS USED FOR SYNTHESIS OF HIV-PROTEASE INHIBITORS |
1994 |
- Dehvid Askin
- Pol' Rejder
- Kaj Rossen
- Richard Dzh.Varsolona
- Kennet M.Uehlls
|
RU2134263C1 |
| 16-SUBSTITUTED 4-AZAANDROSTANES, COMPOUNDS, METHODS OF INHIBITION, PHARMACEUTICAL COMPOSITION |
1994 |
- Filippe L.D'Jurette
- Uil'Jam K.Khagmann
- Tomas Dzh.Lantsa
- Soumia P.Sakhoo
- Gari Kh.Rasmusson
- Richard L.Tolman
- Derek Von Langen
|
RU2142956C1 |
| BENZOXAZINONES AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF FOR INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, TREATMENT AND PROPHYLAXIS OF AIDS AND ARS, METHOD OF INHIBITION OF ACTIVITY OF HIV REVERSE TRANSCRIPTASE, METHOD OF PROPHYLAXIS OF HIV INFECTION, TREATMENT OF HIV AND ARS, COMBINATIONS, METHOD OF SYNTHESIS OF (-)-6-CHLORO- -4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4- -DIHYDRO-2H-3,1-BENZOXAZINE-2-ONE |
1993 |
- Jang Stiven D.
- Britcher Sjuzn F.
- Pejn Linda S.
- Tran Likkhan O.
- Lamma Vill'Jam K. Ml.
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RU2186775C2 |
| 2,3-DIHYDRO-1-(2,2,2-TRIFLUOROETHYL)-2-OXO-5-PHENYL -1H- 1,4-BENZODIAZEPINES AND METHOD OF PREVENTION OR TREATMENT OR ARYTHMIA |
1995 |
- Dehvid A.Klehremon
- Najdzhel Liverton
- Garol'D Dzh.Selnik
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RU2149161C1 |
