QUINOLONE AND ACRIDINE COMPOUNDS, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 1998 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to quinolone and acridine compounds of the formula (I) or their pharmaceutically acceptable salt where R² - H, (C₁-C₆)-alkyl, (C₁-C₄)-fluoroalkyl; R³ - H, CN, (C₁-C₆)-alkyl, (C₁-C₆)-fluoroalkyl, ethanoyl; or R² and R³ form 1,4-butanediyl; R⁴ means a group of the formula (II) ; - H; R⁸ - H, (C₁-C₄)-alkoxy, NO₂, CN, (C₁-C₄)-fluoroalkyl, halogen, (C₁-C₄)-alkyl; R⁹ - H, halogen, (C₁-C₄)-alkyl or (C₁-C₄)-fluoroalkyl; or R⁸ and R⁹ taken together form (C₁-C₃)-alkylenedihydroxy-group; R¹⁰ and R¹¹ - H, -alkyl. Invention proposes also a compound of the formula (III) which is subjected for decarboxylation or dehydration to obtain a compound (I) where R³ - H. Invention proposes other methods for synthesis of compounds (I) also. Pharmaceutical composition has compounds based on these compounds and it shows relaxing effect on bladder smooth muscles. EFFECT: improved methods of synthesis, enhanced effectiveness of compounds. 18 cl, 43 ex, 3 dwg