DERIVATIVES OF PIPERIDINE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND INTERMEDIATE COMPOUNDS Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of piperidine of the general formula (I) where each of R²,R³ means hydrogen atom or R² - H and R³ - OH; R⁴ - phenyl, furyl, pyridyl, 1,3,4-oxadiazole-2-yl or 2-imidazolyl possibly substituted with halogen atom, hydroxy-, alkyl-, alkoxyl-group, COOR^k where R^k - alkyl, -CONR¹R^m where R¹,R^m - H, alkyl, S(O)_nR^N where R^N - alkyl; n = 0, 1 or 2, or R² and R⁴ in common with biradical X¹ and carbon atom to which they bound can form spirocyclic ring - spiro(isobenzofuran-1[3H] -4'-piperirine or oxospiro-(isobenzofuran-1[3H]-4'-piperirine; R³ - H, or their pharmaceutically acceptable salts that show properties of NKA antagonist. EFFECT: improved method of synthesis, valuable pharmacological properties. 16 cl, 3 dwg, 28 ex