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2 124 019

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C1

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IPC

(21) (22)

Application

94046146/04, 1993-05-26

(22)

Actual filing date

1993-05-26

(45)

Published

1998-12-27

(72)

Inventor

Sjuzn Mehri KaasFrank Khehllok IbitinoMarion Dehvid Frehnsiz

(73)

Holder

Dze Prokter Ehnd Gehmbl Farmas'Jutikalz, Ink.

THIOSUBSTITUTED PYRIDINYLBISPHOSPHONIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT Russian patent published in 1998 - IPC

Abstract RU 2124019 C1

FIELD: organophosphorus compounds. SUBSTANCE: invention relates to new thiosubstituted pyridinylbisphosphonic acids of the formula (I): R2-Z-Q-(CR1R1)n-CH[P(O)(OH)2]2 where R1 - H, -SH, -(CH2)mSH or -S-C(O)-R3; R3 is C1-C8-alkyl; m = 1-6; n = 0-6; Q - covalent bond or -NH-; Z - pyridinyl; R2 - H, -SH, -(CH2)mSH, -(CH2)mS-C(O)R3 or NH-C(O)-R4--SH where R3 and m has values indicated above; R4 is C1-C8--alkylene, or their pharmaceutically acceptable salts or esters. Invention relates to also pharmaceutical composition for treatment or prophylaxis of sicknesses associated with anomal metabolism of calcium and phosphorus and containing compound of the formula (I) at effective amount and to a method of treatment of patients with indicated sickness. EFFECT: improved method of synthesis, enhanced effectiveness of treatment. 10 cl, 17 ex

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RU 2 124 019 C1

Authors

Sjuzn Mehri Kaas

Frank Khehllok Ibitino

Marion Dehvid Frehnsiz

Dates

1998-12-27—Published

1993-05-26—Filed

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