FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to cyclic urea compounds of the formula (I) 
where R1,R2,R3 - hydrogen, chlorine, fluorine or bromine atom; R4 is C3-6-alkylene; A - dimethylamino-, diethylamino-, bis-2-hydroxyethylamino-, bis-[(1-methyl)ethyl] amino-, N-(2-hydroxyethyl)-N-methylamino-, 4-(2-hydroxyethyl)-1- -piperazinyl-, 4-[[(1-methyl)ethyl] ] -1-piperazinyl-, 4-[(2- -methyl)propyl]-1-piperazinyl-, 4-hexyl-1-piperazinyl-, 1-piperazinyl-4-methyl-1-piperazinyl-, 4-n-butyl-1-pipera-zinyl-, 4-ethyl-1-piperazinyl-group; R5 is C1-2-alkylene, or their pharmaceutically acceptable salts or esters that show an antiarrythmic and antifibrillatory activity. EFFECT: enhanced effectiveness of compounds and treatment. 7 cl, 16 ex
| Title |
Year |
Author |
Number |
| UREA 4-OXOCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT |
1992 |
- Stehnford Sal'Vatore Pelozi, Ml.
- Chia-Nien Ju
- Mark Artur Kalkagno
|
RU2130935C1 |
| COMPOUNDS OF CYCLIC URETHAN OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF HUMAN AND OTHER MAMMALIAN TREATMENT SUFFERING WITH CARDIAC ARRHYTHMIA AND/OR ATRIAL FIBRILLATION, A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF PATIENTS WITH ARRHYTHMIA AND FIBRILLATION |
1992 |
- Stehnford Sal'Vatore Pelozi
- Chia-Nien Ju
|
RU2125568C1 |
| UREA OXOCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION, TREATMENT METHOD |
1992 |
- Pelozi Sal'Vatore Stehnford Ml.
- Ju Chia-Nien
- Kalkagno Mark Artur
|
RU2221788C2 |
| METHOD OF OSTEOPOROSIS TREATMENT |
1992 |
- Ehnn Danbar Giddis
- Rodzheli Uehjt Bojs
|
RU2112515C1 |
| USE OF BIS-PHOSPHONATES AND PARATHYROID GLAND EXTRACT FOR OSTEOPOROSIS TREATMENT |
1992 |
- Ehnn Danbar Dzheddes[Us]
- Roudzhli Vejt Bojs[Us]
|
RU2104699C1 |
| METHOD OF SYNTHESIS OF 1,3-DISUBSTITUTED 4-OXO-CYCLIC UREAS |
1999 |
- Mehtson Patritsija Ehnn
- Godlevski Majkl Selden
|
RU2194705C2 |
| METHOD OF SYNTHESIS OF 1-[[[5-(4-CHLOROPHENYL)-2-FURANYL]METHYLENE]AMINO]- 3-[4-(4-METHYL-1-PIPERAZINYL)BUTYL]-2,4-IMIDAZOLIDINEDIONE DIHYDROCHLORIDE |
1999 |
- Mehtson Patritsija Ehnn
- Godlevski Majkl Selden
- Korroz Daniehl
- Guggisberg Iv
|
RU2194706C2 |
| USE OF PHOSPHONATES AND NONSTEROID ANTIINFLAMMATORY DRUGS FOR TREATMENT OF PATIENTS WITH ARTHRITIS, METHOD OF TREATMENT |
1993 |
- Kristin Khovanchik
- Marion Dehvid Frehnsis
- Richard Allen Andervud
|
RU2119794C1 |
| METHOD OF PREPARING QUINOLINYL LACTAMS OR SALTS THEREOF |
1992 |
- Ronal'D Jugen Uajt
- Tomas Prosser Demut, Ml.
|
RU2130938C1 |
| SULFUR-CONTAINING PHOSPHONIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS AND PHARMACEUTICAL COMPOSITION BASED ON SAID |
1993 |
- Sjuzn Mehri Kaas
- Frank Khehllok Ibitino
- Marion Dehvid Frehnsiz
|
RU2136691C1 |
