FIELD: pharmaceutical industry. SUBSTANCE: present invention describes novel quaternary nitrogen- containing phosphonate compounds and pharmaceutically acceptable salts and esters thereof having general formula (I). The present invention also describes pharmaceutical compositions containing effective and safe amount of the claimed compound an pharmaceutically acceptable carriers. The present invention describes processes for treatment and prophylaxis of pathological states which are typical of calcium and phosphate metabolism disorders such as osteoporosis, rheumatoidal arthritis and osteoarthritis in humans and mammals and medical treatment of tooth calculuses, tooth deposits and gingivitis. The claimed process comprises adding safe and effective amount of compound or composition of the present invention. EFFECT: improved properties of the pharmaceutical composition. 11 cl, 31 ex, 1 dwg
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Year |
Author |
Number |
| USE OF PHOSPHONATES AND NONSTEROID ANTIINFLAMMATORY DRUGS FOR TREATMENT OF PATIENTS WITH ARTHRITIS, METHOD OF TREATMENT |
1993 |
- Kristin Khovanchik
- Marion Dehvid Frehnsis
- Richard Allen Andervud
|
RU2119794C1 |
| THIOSUBSTITUTED PYRIDINYLBISPHOSPHONIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT |
1993 |
- Sjuzn Mehri Kaas
- Frank Khehllok Ibitino
- Marion Dehvid Frehnsiz
|
RU2124019C1 |
| SULFUR-CONTAINING PHOSPHONIC ACIDS OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS AND PHARMACEUTICAL COMPOSITION BASED ON SAID |
1993 |
- Sjuzn Mehri Kaas
- Frank Khehllok Ibitino
- Marion Dehvid Frehnsiz
|
RU2136691C1 |
| METHOD OF OSTEOPOROSIS TREATMENT |
1992 |
- Ehnn Danbar Giddis
- Rodzheli Uehjt Bojs
|
RU2112515C1 |
| USE OF BIS-PHOSPHONATES AND PARATHYROID GLAND EXTRACT FOR OSTEOPOROSIS TREATMENT |
1992 |
- Ehnn Danbar Dzheddes[Us]
- Roudzhli Vejt Bojs[Us]
|
RU2104699C1 |
| COMPOUNDS OF CYCLIC URETHAN OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF HUMAN AND OTHER MAMMALIAN TREATMENT SUFFERING WITH CARDIAC ARRHYTHMIA AND/OR ATRIAL FIBRILLATION, A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF PATIENTS WITH ARRHYTHMIA AND FIBRILLATION |
1992 |
- Stehnford Sal'Vatore Pelozi
- Chia-Nien Ju
|
RU2125568C1 |
| CYCLIC UREA COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT |
1992 |
- Stehnford Sal'Vatore Pelozi
- Chia-Nien Ju
|
RU2142461C1 |
| UREA 4-OXOCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT |
1992 |
- Stehnford Sal'Vatore Pelozi, Ml.
- Chia-Nien Ju
- Mark Artur Kalkagno
|
RU2130935C1 |
| DERIVATIVES OF 5-HYDRAZINOQUINOLONE, COMPOSITION FOR TREATMENT AND PROPHYLAXIS OF INFECTION DISEASE, METHOD OF TREATMENT AND PROPHYLAXIS |
1993 |
- Demut Tomas Prosser
- Uajt Ronal'D Judzhin
|
RU2126000C1 |
| METHOD OF PREPARING QUINOLINYL LACTAMS OR SALTS THEREOF |
1992 |
- Ronal'D Jugen Uajt
- Tomas Prosser Demut, Ml.
|
RU2130938C1 |
