FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes crystalline monohydrates of endo-2,3- -dihydro-N-(8-methyl-8-azabicyclo-[3,2,1] -oct-3-yl)-2-oxo- -1H-benzimidazole-1-carboxamide and endo-3-ethyl-2,3-dihydro- -N-(8-methyl-8-azabicyclo-[3,2,1] -oct-3-yk)-2-oxo-1H-benzimi- -dazole-1-carboxamide hydrochlorides eliciting valuable pharmacological properties and high stability at different temperatures and relative humidity. Invention proposes also a method of synthesis of these compounds and pharmaceutical composition containing these compounds. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 5 cl, 12 tbl, 4 dwg, 10 ex
| Title |
Year |
Author |
Number |
| DERIVATIVES OF BENZIMIDAZOLONE, MIXTURE OF THEIR ISOMERS OR THEIR ACID ADDITIVE SALTS AS ANTAGONIST OF RECEPTOR 5HT AND 5HT |
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- Dzhuzeppe Bietti[It]
- Franko Borsini[It]
- Mario Turkoni[It]
- Ehttore Dzhiral'Do[It]
- Mario Bignotti[It]
|
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- Dzhenet Kristin Uajt[Gb]
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|
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- Dall Gari Moris
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- Gatto Gregori Dzh.
- Dzhenus Dzhon
- Dzhordan Kristen G.
- Meht'Ju Dzhejkob
- Mazurov Anatolij A.
- Mjao Lan'
- Mun'Os Khulio A.
- Pfajffer Inigo
- Pfajffer Sondra
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|
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- Dulenko Vladimir Ivanovich
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- Zabudkin Aleksandr Fridrikhovich
- Khabarov Konstantin Mikhajlovich
|
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|
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- Song Kho Joung
- Li Dae Jon
- Baek Sung Joon
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- Park Tae Kio
- Voo Sung Kho
- Kim Jong Zu
|
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|
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- Tom Norma Zhaklin
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|
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| HETEROCYCLIC COMPOUNDS OR THEIR PHARMACEUTICALLY ACCEPTABLE ADDITIVE ACID SALTS, OR HETEROCYCLIC COMPOUND N-OXIDE, OR ITS ADDITIVE ACID SALT |
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|
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| FURO- AND THIENO[2,3-b]-QUINOLINE-2-CARBOXAMIDES, METHOD OF PRODUCTION AND ANTITUBERCULOUS ACTIVITY |
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|
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