FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes crystalline monohydrates of endo-2,3- -dihydro-N-(8-methyl-8-azabicyclo-[3,2,1] -oct-3-yl)-2-oxo- -1H-benzimidazole-1-carboxamide and endo-3-ethyl-2,3-dihydro- -N-(8-methyl-8-azabicyclo-[3,2,1] -oct-3-yk)-2-oxo-1H-benzimi- -dazole-1-carboxamide hydrochlorides eliciting valuable pharmacological properties and high stability at different temperatures and relative humidity. Invention proposes also a method of synthesis of these compounds and pharmaceutical composition containing these compounds. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 5 cl, 12 tbl, 4 dwg, 10 ex
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Year |
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Number |
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