DERIVATIVE OF 8-AZABICYCLO[3,2,1]OCT-2-ENE, METHODS OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 2002 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a novel derivative of 8-azabicyclo[3.2.1] oct-2-ene of the formula (1) where R means H, alkyl, cycloalkyl, phenyl or benzyl; R¹ means where R² means H, alkyl, cycloalkyl or furanyl, thienyl, oxazolyl, isoxazolyl, pyridyl or thiazolyl. Indicated heteroaryl group can be substituted with one or more substituents taken among alkyl, cycloalkyl, alkoxy-group, halogen atom, CF₃, OCF₃,, CN, amino-group, nitro-group, phenyl or furanyl; or naphthyl, benzofuranyl, benzothienyl, benzimidazolyl, benzothiazolyl, quinolinyl, isoquinolinyl, thieno[3.2-b] thienyl or thieno[2.3-b] thienyl possibly substituted with one or more substituents taken among the group comprising alkyl, cycloalkyl, alkoxy-group, halogen atom, CF₃, OCF₃,, CN, amino-group, nitro-group, phenyl. Compounds can be used as ligands of nicotine acetylcholine receptors. EFFECT: improved methods of synthesis, valuable pharmacological properties. 7 cl, 1 tbl