DERIVATIVES OF ERGOLINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, ergot alkaloids. SUBSTANCE: invention relates to derivatives of ergoline of the general formula (I) where R₁ is C_1-4-alkyl; A - OH, or a residue of the formula (a) , (b) , (c) ; R₂ - hydrogen, bromine atom, -S-C_1-4-alkyl; - C_1-5-alkyl or hydrogen atom; n = 0, 1 or 2; m = 1 or 2; R₄ - hydrogen atom, C_1-7-alkyl, C_3-7-cycloalkyl, adamantyl, C_1-5-alkylphenyl, C₂-alkenylphenyl, phenyl substituted with CF₃ or one or two alkoxy-groups, naphthyl, benzothiophene, alkenylfuryl, 5-6-membered heterocyclic ring containing 1-2 heteroatoms taken from N, S and possibly substituted with alkyl, phenyl or halogen atom; X is O or S; or their pharmaceutically acceptable salts that can be used for state control caused by serotonine-ergic disorders. EFFECT: improved method of synthesis. 5 cl, 2 tbl, 48 ex