FIELD: organic chemistry. SUBSTANCE: invention relates to 5-amino-2,4,6,7-tetramethyl-2- -(4-phenylpiperidinomethyl)-2,3-dihydrobenzo-[b]-furan enantiomer crystalline salts showing stability and increased water solubility. They can be used as effective inhibitors of lipid peroxides formation. Compounds are synthesized by interaction of 5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperi- -dinomethyl)-2,4-dihydrobenzo-[b] -furan with an optically active organic acid or by interaction of 5-amino-2,4,6,7- -tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo- -[b] -furan with acid. Pharmaceutical composition prepared on the base said inhibits lipid peroxide formation. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 15 cl, 3 dwg, 1 tbl, 12 ex
| Title |
Year |
Author |
Number |
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1997 |
- Okhkava Sigenori
- Khasimoto Tadatosi
- Fukatsu Kokhdzi
|
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1992 |
- Tetsuja Aono[Jp]
- Sigenori Okhkava[Jp]
- Takajuki Doi[Jp]
|
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| DERIVATIVES OF PYRIDOPYRIMIDINE, THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION, A METHOD OF TREATMENT |
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- Suiti Furujja
- Tetsujja Okhtaki
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1995 |
- Jasuo Sugijama
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- Minoru Khirata
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| HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF ANTAGONISM OF ANGIOTENSIN-II |
1992 |
- Takekhiko Naka
- Esijuki F. Inada
|
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| METHOD OF PRODUCING DERIVATIVES OF 1,5-BENZOTHIAZEPIN OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
0 |
- Khirosada Sugikhara
- Kokhei Nisikava
- Katsumi Ito
|
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| METHOD OF PRODUCING SPIROBENZOFURANS |
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- Khirosada Sugikhara
- Masazumi Vatanabe
- Mitsuru Kavada
- Isuke Imada
|
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| VERSIONS OF METHOD FOR PRODUCING DIHYDROPYRIDINE DERIVATIVES |
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- Kani Meguro
- Akinobi Nagaoka
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| METHOD FOR SYNTHESIS OF AMINE-SUBSTITUTED DERIVATIVE OR THEIRS ACID-ADDITIVE SALTS |
0 |
- Susumu Tsusima
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- Minoru Khirata
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SU1706386A3 |
