DERIVATIVES OF PYRIDOPYRIMIDINE, THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION, A METHOD OF TREATMENT Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: invention describes new derivatives of pyridopyrimidine of the formula (A) where means -(CH₂)_m- (m = 0, 1 or 2); n = 1-3; R¹ means hydrogen atom; C_1-6-alkyl-group that can be optionally substituted with one of substituents taken from quinolyl or indolyl; phenyl group that can be optionally substituted with at least one C_1-6-alkoxy-group; or phenyl-C_1-3-alkyl-group that can be optionally substituted with at least one substituent taken from C_1-6-alkoxy- and C_1-6-alkylthio-group; R² means hydrogen atom or C_1-6-alkyl-group; R³ means phenyl or naphthyl group that can be optionally substituted with at least one substituent taken from C_1-6-alkyl, C_1-6-alkoxy-, C_1-6-alkylenedioxy-group, halogen atom, nitro-, cyano-group, phenyl, C_3-7-cycloalkyl; pyridyl that can be optionally substituted with C_1-6-alkyl; thienyl that can be optionally substituted with C_1-6-alkyl; quinolyl that can be optionally substituted with oxo-group or hydroxyl-group; quinolonyl; benzofuryl or benzothienyl that can be optionally substituted with C_1-6-alkyl; R⁴ means a group -COO-COOR⁶ where R⁶ means hydrogen atom; C_1-6-alkyl group optionally substituted with at least one substituent taken from C_3-7-cycloalkyl-group, quinolyl-group, carboxyl-group, cyano- and phenyl-group; or C_3-7-cycloalkyl; or a group -COA-R⁷R⁸ where R⁷ and R⁸ mean independently hydrogen atom or C_1-6-alkyl group; R⁵ means hydrogen atom; C_1-6-alkyl group or phenyl-group that can be optionally substituted with C_1-6-alkylenedioxy-group, or its salt. Invention describes also a method of synthesis of compounds of the formula (A), pharmaceutical compositions based on compound of the formula (A) and a method of an antagonistic effect on endothelial receptors in treatment of patients with renal failure, myocardium infarctum, hypertension, cerebral infarctum, angina pectoris, arteriosclerosis, hepatopathy, pulmonary hypertension, bronchial asthma, organohypofunction caused by operation or organ transplantation, New compounds of the formula (A) and pharmocompositions based on said can be used in medicine. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 20 cl, 44 tbl, 46 ex