CYCLIC ETHER, METHODS OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF SODIUM CHANNEL MODULATION Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes a novel cyclic ether of the formula (I) where each R¹ and R² means hydrogen atom, lower alkyl or C_1-6-alkylcarbonyl; R³, R⁴, R⁵ each means lower alkyl; R⁶ means lower alkyl; Ar means C_6-14-aryl that can be substituted with halogen atom, C_1-6-alkyl, C_1-6-alkoxy-group or C_1-3-alkylenedioxy-group; ring A means 5-8-membered saturated nitrogen-containing heterocyclic ring; X means lower alkylene; Y means carbon or nitrogen atom; Za means the group of formulas (a) , (b) , (c) or (d) where R⁷ means hydrogen atom or C_6-14-aryl that can be substituted with halogen atom or C_1-6-alkoxy-group; R¹⁰ means hydrogen atom or C_7-16-aralkyl; Zb means a bond or bivalent hydrocarbon group taken among the group including C_1-8-alkylene, C_2-8-alkenylene or group of the formula: -(CH₂)_p-M-(CH₂)_q- where p and q each means a whole number from 0 to 8 and p + q means a whole number from 1 to 8; M means O or NR⁹ where R⁹ means hydrogen atom being each bivalent group can be substituted with C_6-14-aryl; and m means a whole number from 1 to 3, or its salt that can be used for preparing pharmaceutical composition used for sodium channel modulation. Invention describes method of synthesis of ether, pharmaceutical composition and method of modulation of sodium channel activity. EFFECT: new cyclic ether indicated above, improved method of synthesis, valuable pharmacological properties of ether. 26 cl, 5 tbl