ANTIHYPERTRIGLYCERIDEMIC COMPOSITION (VARIANTS), METHOD OF ITS PREPARING, METHOD OF TREATMENT OR PROPHYLAXIS OF HYPERTRIGLYCERIDEMIA Russian patent published in 2001 - IPC

FIELD: organic chemistry, medicine. SUBSTANCE: composition has effective amount of compound of the formula: where R₁ is C_1-7-alkyl group that can be substituted; E is halogen atom or one or two C_1-3-alkoxy- groups; D is oxygen or sulfur atom; Y is a substituent including carboxyl group that can be substituted or optionally substituted heterocyclic group having hydrogen atom that can be deprotonated; W is halogen atom, or its pharmacologically acceptable salt. The second composition has effective amount of compound of the formula: where R₁ is C_1-7-alkyl group that can be substituted; R₂ is hydrogen atom; R₃ is phenyl group substituted with halogen atom or one or two C_1-3-alkoxy- groups; X₁ is CH₂; Y is carboxyl group that can be esterified, carboxyl group that can be substituted or optionally substituted heterocyclic group containing hydrogen atom that can be deprotonated; W is halogen atom, or its pharmacologically acceptable salt. Invention relates to also method of prophylaxis or treatment of mammals with hypertri-glyceridemia that involves administration of composition in the effective dose. Method of preparing the composition involves mixing and/or stirring the effective amount of indicated compound or its salt with acceptable diluting agent, filling agent or carrier. Invention provides to decrease plasma triglycerides concentrations that is vital essential for prophylaxis and therapy of atherosclerotic diseases. EFFECT: enhanced effectiveness of prophylaxis and treatment, improved method of composition preparing. 18 cl, 7 tbl, 36 ex