PROCESS FOR PREPARING 16-α-METHYLATED STEROIDS Russian patent published in 1999 - IPC

Abstract RU 2125575 C1

FIELD: medicine. SUBSTANCE: present invention describes process for preparing 16-α methylated steroids of general formula I: α. Said process comprises stage of methylation of 16-unsubstituted steroid derivative in the presence of copper-based catalyst and stage of hydrolysis. Compound of formula II: is treated by methylation in the presence of copper based catalyst and the resulting methylated enolate is then hydrolyzed to produce the corresponding enol which is oxidized with molecular oxygen in the presence of reducing agent that forms intercomplex organocopper compound to obtain the desired compound. The claimed process is simple and suitable in operation. The present invention describes compounds of formula III: with single or double bond as intermediate products for synthesis of compounds I which have antiinflammatory properties. EFFECT: more efficient preparation process. 11 cl, 11 ex

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RU 2 125 575 C1

Authors

Zhan Bjuandia

Patrik Russel'

Mishel' Viva

Dates

1999-01-27—Published

1993-06-10—Filed