PREGNANE DERIVATIVES SUBSTITUTED IN 17-POSITION, METHOD OF THEIR SYNTHESIS, INDUSTRIAL PRODUCTS, PHARMACEUTICAL COMPOSITION Russian patent published in 2002 - IPC

FIELD: organic chemistry, steroids, pharmacy. SUBSTANCE: invention describes compounds of the formula (I) α- where means either halogen atom, hydroxyl or R₁ and R₁ in common form the second bond and R₂ means halogen or hydrogen atom; Z is taken among alkylthio-group with 1-8 carbon atoms that can be substituted if necessary, arylthio-group that can be substituted if necessary with OH or OAc, alkyloxy-group with 1- 8 carbon atoms, halogen atom, cyano-group being dotted line means the second possible bond with exception for 9R₂ fluoro- 11α- hydroxy -16β- methyl-21-chloro-pregna- 1,4-diene-3,20-dione under condition that if α- and R₁ in common form a double bond then Z is not halogen atom, and their additive salts also. Invention describes also method of their synthesis, intermediate compounds of this method and pharmaceutical composition based on thereof eliciting anti-inflammatory and immuno-suppressing activity. EFFECT: improved method of synthesis, valuable medicinal properties. 8 cl, 4 tbl, 8 ex