INDOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF Russian patent published in 1998 - IPC

Abstract RU 2124012 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of indole of the formula (I) where A - direct bond or alkyl; R₁ - hydrogen or alkyl; W, X, Y and Z each and independently means oxygen, sulfur, nitrogen or carbon at condition that at least one of W, X, Y or Z is nitrogen; one of R₂, R₃, R₄ and R₅ means C_1-6-alkyl, phenyl, C_1-3-alkylphenyl and others - hydrogen being the indicated phenyl is substituted possibly with C_1-4-alkyl, halogen, C_1-4-alkoxy-group, hydroxyl. Invention relates to also a pharmaceutical composition on the basis of compound of the formula (I) which shows activity of 5-HT₁ and active compounds can be used for treatment of patients. Invention relates to also compounds of the formula (II) and (III) that can be used as intermediate substances in the process of synthesis of derivatives of indole of the formula (I). EFFECT: improved method of synthesis, high activity of compounds. 20 cl, 11 ex

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RU 2 124 012 C1

Authors

Dzhon E.Mejkor

Elanta T.Novakovski

Dates

1998-12-27—Published

1993-03-03—Filed