DERIVATIVES OF ACYLAMINOINDOLE AND AMINOINDOLE Russian patent published in 1998 - IPC

Abstract RU 2110516 C1

FIELD: organic chemistry. SUBSTANCE: compounds are synthesized by interaction of the corresponding aminoindole derivatives with carboxylic acid in the presence of an agent activating carboxylic acid in inert solvent. Carbonyldiimidazole is used as a preferable an acid-activating agent. 1,4-Dioxane diethyl ester or tetrahydrofuran is used as a solvent. Reaction is carried out at 0-65 C. Product: (R)-3-(N-benzylhydroxycarbonylpyrrolidine-2-yl-carbonyl)-5-di- benzylamino-1H-indole, m. p. is 176-177 C, |α|²⁵ = +112 degree (in tetrahydrofuran, c = 1.0). Synthesized compounds can be used as pharmaceutical preparations for treatment of sicknesses caused by insufficient serotonin neurotransmission. EFFECT: improved method of synthesis. 7 cl, 1 tbl

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RU 2 110 516 C1

Authors

Dzhon I.Mehjkor[Us]

Dates

1998-05-10—Published

1993-03-04—Filed