FIELD: pharmaceutical industry. SUBSTANCE: claimed process for preparing any of forms: anhydrous 7-[(7-(S)amino-5-azaspiro(2,4) heptan-5-yl)-8- chloro-6-fluoro-1-[(1R, 2S)-2-fluorocyclopropyl)-4-oxo- 1,4-dihydroquinoline-3-carboxylic acid 1/2 hydrate, 1 hydrate and 3/2 hydrate comprises treating compound in aqueous solvent or water, or recrystallizing compound from aqueous solvent or water. The present invention also describes said anhydrous acid based composition having antibacterial activity. Anhydrous acid also shows antimicrobial activity. EFFECT: improved properties of the pharmaceutical composition. 7 cl, 4 dwg, 7 ex, 1 tbl
| Title |
Year |
Author |
Number |
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1993 |
- Isao Khajakava[Jp]
- Jouiti Kimura[Jp]
- Khisasi Takakhasi[Jp]
|
RU2100351C1 |
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- Jusuke Jukimoto[Jp]
- Tokhru Kanejuti[Jp]
- Ioiti Kimura[Jp]
- Katsukhiro Kavakamis[Jp]
- Isao Khajjakava[Jp]
|
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1993 |
- Makoto Takemura
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- Norikazu Matsukhasi
|
RU2125046C1 |
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1989 |
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- Euiti Kimura[Jp]
|
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2000 |
- Jazaki Akira
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- Okhsita Esikhiro
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- Amano Khirotaka
|
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2012 |
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- Minagava Vataru
- Funada Keiko
- Nagao Muneki
|
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| METHOD OF N-(1 |
0 |
- Isao Khayakava
- Eiti Kimura
|
SU1792416A3 |
| TRI- OR TETPA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES |
2006 |
- Takakhasi Khisasi
- Inagaki Khiroaki
- Komorija Satosi
- Takemura Makoto
- Mijauti Rie
|
RU2420524C2 |
| CRYSTALLINE 3[-2[4-(3-CHLORO-2-METHYLPHENYL)-1- PIPERAZINYL]ETHYL]-5,6-DIMETHOXY-1-[4-IMIDAZOLYLMETHYL]- 1H-INDAZOLE DEHYDROCHLORIDE AND 3,5-HYDRATE THEREOF, AND METHODS OF PREPARATION THEREOF |
1995 |
- Jamamoto Kendziro
- Mijadera Akikhiko
- Kitaoka Khiroaki
|
RU2152941C1 |
| STABILIZED LIQUID PREPARATION FORMS |
2001 |
- Araki Masanori
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- Matsukava Azusa
|
RU2295342C2 |
