7-{(3S,4S)-3-[(CYCLOPROPYLAMINO)METHYL]-4-FLUOROPYRROLIDIN-1-YL}-6-FLUORO-1-(2-FLUOROETHYL)-8-METHOXY-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID CRYSTAL Russian patent published in 2017 - IPC C07D401/04 A61K31/4709 A61P31/04 

Abstract RU 2615509 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, in particular, to a hydrochloride salt crystal, a hydrochloride salt hydrate crystal and methane sulphonate salt crystal 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid. Invention also relates to an antibacterial pharmaceutical preparation based on said crystal, a method of producing said crystals.

EFFECT: technical result: obtained crystals have high solubility in water, as well as high storage stability.

19 cl, 6 dwg, 4 tbl, 13 ex

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RU 2 615 509 C2

Authors

Araya Itiro

Goto Akinori

Minagava Vataru

Funada Keiko

Nagao Muneki

Dates

2017-04-05Published

2012-11-09Filed