FIELD: organic chemistry. SUBSTANCE: product: 1-(1,2-cis-2-fluorocyclopropyl)-substituted quinolone derivative of the formula (I) $$$ consisting of a single stereoisomer where $$$ means methyl group, difluoromethyl group and others; $$$ means the saturated nitrogen-containing heterocyclic group; A means C-$$$ or nitrogen atom; each of $$$ and $$$ means halogen atom; $$$ and Z mean hydrogen atom and others. The synthesized compound shows antibacterial property. EFFECT: improved method of synthesis. 13 cl, 3 dwg, 2 tbl
Title |
Year |
Author |
Number |
METHOD OF SYNTHESIS OF 8-CHLOROQUINOLONE DERIVATIVE |
1991 |
- Jusuke Jukimoto[Jp]
- Tokhru Kanejuti[Jp]
- Ioiti Kimura[Jp]
- Katsukhiro Kavakamis[Jp]
- Isao Khajjakava[Jp]
|
RU2049778C1 |
BICYCLIC DERIVATIVES OF 1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID OR THEIR SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY |
1993 |
- Makoto Takemura
- Juiti Kimura
- Norikazu Matsukhasi
|
RU2125046C1 |
SPIROCOMPOUND OR SALTS THEREOF, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED THEREON HAVING ANTIMICROBIAL ACTIVITY |
1989 |
- Isao Khajakava[Jp]
- Sokhgo Atarasi Masazumi Jmamura[Jp]
- Euiti Kimura[Jp]
|
RU2094432C1 |
PROCESS FOR SELECTIVE PREPARATION OF 7-[(7-(S)-AMINO-5- AZASPIRO [2,4]HEPTAN-5-YL) -8-CHLORO-6-FLUORO-1- [(IR,2S)-2-FLUOROCYCLOPROPYL)-4-OXO-1,4-DEHYDROAMINOLINE- 3-CARBOXYLIC ACID 3/2 HYDRATE, ANHYDROUS 7-[(7-(S)-AMINO- 5-AZASPIRO [2,4]HEPTAN-5-YL)-8-CHLORO-6-FLUORO-1-(1R,2S)- 2-FLUOROCYCLOPROPYL-4-OXO-1,4-DIHYDROQUINOLINE-3- CARBOXYLIC ACID AND PHARMACEUTICAL COMPOSITION HAVING ANTIBACTERIAL ACTIVITY |
1994 |
- Iuiti Kimura
- Katsukhiro Kavakami
- Norimasa Mikata
- Kejdzi Utijama
- Tazuo Uemura
- Juzuke Jukimoto
|
RU2126402C1 |
AGENT AGAINST ACID-RESISTANT MICROORGANISMS CONTAINING HETEROCYCLIC DERIVATIVES OF BENZOXAZINE AS ACTIVE COMPONENT |
2001 |
- Takemura Makoto
- Takakhasi Khisasi
- Kavakami Katsukhiro
- Namba Kendzi
- Tanaka Maiumi
- Mijauti Rie
|
RU2297420C2 |
TRI- OR TETPA-SUBSTITUTED-3-AMINOPYRROLIDINE DERIVATIVES |
2006 |
- Takakhasi Khisasi
- Inagaki Khiroaki
- Komorija Satosi
- Takemura Makoto
- Mijauti Rie
|
RU2420524C2 |
AGENT AGAINST ACID-RESISTANT MICROORGANISMS CONTAINING PYRIDONE CARBOXYLIC ACIDS AS ACTIVE COMPONENT |
2001 |
- Takemura Makoto
- Takakhasi Khisasi
- Kavakami Katsukhiro
- Namba Kendzi
- Tanaka Maiumi
- Mijauti Rie
|
RU2299205C2 |
DERIVATIVES OF AMINOMETHYLPYRROLIDINE WITH AROMATIC SUBSTITUTES |
2000 |
- Takemura Makoto
- Takakhasi Khisasi
- Kavakami Katsukhiro
- Takeda Tosijuki
- Mijauti Rie
|
RU2255938C2 |
METHOD OF N-(1 |
0 |
- Isao Khayakava
- Eiti Kimura
|
SU1792416A3 |
COMPOSITION FOR COMBATTING IMMUNITY DEFICIENCY VIRUS |
1991 |
- Genkiti Okhta[Jp]
- Mitsuru Furusava[Jp]
- Dzunko Nozaki[Jp]
- Josinari Sato[Jp]
- Takasi Iino[Jp]
|
RU2044544C1 |