BICYCLIC DERIVATIVES OF 1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID OR THEIR SALTS AND PHARMACEUTICAL COMPOSITION SHOWING ANTIBACTERIAL ACTIVITY Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to bicyclic derivatives of 1,4-dihydro-4-oxoquinoline-3-carboxylic acid of the formula (I) where X¹ and X² - halide atom; A is a group ; X³ - hydrogen, halide or alkyl; R - hydrogen or ethoxycarbonyl; R¹ is H or amino-group; R² - bicyclic heterocyclic substituent of the formula (A) R³ where R⁴ and - hydrogen or taken together they form a bond; Y is R⁵ where C_2-5 - H or -CH₂--acyl; Z - oxygen atom or ; m and n are a whole numbers from 0 to 2 independently being m + n = 2-3; p, q and r - are whole numbers from 0 to 3 and their sum a whole number from 0 to 3. Invention proposes a pharmaceutical composition containing a compound of the formula (I) as an active component that shows antibacterial activity. EFFECT: improved method of synthesis, enhanced antibacterial activity of compounds. 25 cl, 1 tbl, 42 ex