FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes amino-derivatives of oxo- or hydroxy-substituted hydrazines of formulas: XN(R)CH- -
-C(O)Y (IC) and XN(R)CH-
-C(O)Y (ID) where R is H; X is H, (C1-C10)-aryl-(C1-C6)-alkoxycarbonyl and others; R21 is (C6-C10)-aryl-(C1-C6)- -alkyl; R22 is H; R23 is (C1-C6)-alkyl, (C6-C10)-aryl-(C1-C6)-alkyl and others; R24 is H; Y is (C1-C6)-alkyl, (C1-C6)-alkoxy and others. These compounds are synthesized by interaction of compound of the formula X-NR-
with compound of the formula HN-
-C(O)Y. Compounds (IC) and (ID) can be used in pharmaceutical compositions as an active agent to inhibit retrovirus protease, in part, at acquired immunodeficiency syndrome (AIDS) that gives possibility to use these compounds for treatment of patients with viral HIV-infections. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 11 cl, 3 tbl, 38 ex
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