FIELD: organic chemistry, medicine, virology, pharmacy. SUBSTANCE: invention relates to derivatives of hydroxyethylaminosulfoneamides of the formulas (I) 
, (II) 
, (III) 
where R means phenyl-C1-C8-alkoxy-carbonyl where phenyl can be substituted with C1-C8-alkoxy-group, quinolinylcarbonyl, mono- or di-C1-C8-alkylamino-C1-C8-alkanoyl; R′ means H, C1-C8-alkyl; R1 means H, C1-C8-alkyl, C2-C8-alkenyl, 
amino acid side-chain, for example, glycine; R1 and R2″ both mean H; R2 means phenyl-C1-C8-alkyl; R3 means H, C1-C8-alkyl, C1-C8-alkoxy-C1-C8-alkyl, C2-C8-alkenyl; R4 means C1-C8-alkyl, phenyl, methoxyphenyl; R6 is H; x = 1, 2; t = 0 or 1. Compounds of formulas (I), (II), (III) relate to inhibitors of retroviral protease and can be used in pharmaceutical composition for inhibition of HIV protease and in method of inhibition of HIV infection also. EFFECT: improved method of inhibition of protease and treatment of infection, valuable medicinal properties of compounds. 61 cl, 2 dwg, 25 tbl, 33 ex
