MONOCLONAL ANTIBODIES RAISED TO HUMAN GLYCOPROTEIN P Russian patent published in 1999 - IPC

FIELD: medicine, immunology. SUBSTANCE: monoclonal antibodies show specificity and bind human glycoprotein P at high effectiveness and can be used for detection of human MYA-cells if their part of cellular population is very low or they produce human glycoprotein P at very low quantities. Indicated monoclonal antibodies can exhibit whole antibodies or an antigen-binding fragment and can be obtained using hybridoma procedure of recombinant DNA method. Monoclonal antibodies can be used for detection or purification of cells producing human glycoprotein P, in part, in case when they present in heterogeneous cellular populations and for testing multiple resistance to antibiotics in cells, for example, in cancer cells. EFFECT: enhanced effectiveness of antibodies proposed. 5 cl, 1 tbl, 1 dwg, 6 ex